‘Bad news’ gene loses its punch when you hit 90s

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Washington, October 26: A gene linked to the risk of developing Alzheimer’s, heart disease and diabetes becomes less important to quality of life once people reach their 90s, a Mayo Clinic study shows.

At that point, good friends and a positive attitude have a bigger impact, the researchers say.

Researchers used the National Institutes of Health-supported Rochester Epidemiology Project, a database of patient records in Olmsted County, Minn., to find people ages 90 to 99 living on their own or in long-term care.

The 121 participants completed an interview, a physical exam and a quality-of-life questionnaire.

Participants were divided into groups based on their cognitive function, to sort out the effects of age and disease on well-being, and blood samples were taken for genotyping.

Researchers discovered that those who carried the gene in question, known as ApoE4, were no worse off than others in the study.

“We found if people had good physical, intellectual, and emotional well-being, more social connectedness, and if they perceived themselves to have better coping skills, they felt they had better quality of life,” said co-author Maria Lapid, M.D., a Mayo Clinic psychiatrist.

“The study shows that the ApoE4 genotype doesn’t determine what your quality of life will be, and that, regardless of your gender, environmental factors play a significant role in your physical, emotional, spiritual, and social well-being.

“You can have good quality of life regardless of this gene,” she added.

The study has been published in the Journal of American Medical Directors Association. (ANI)