Protein discovery offers new hope against recurrent breast cancer

Washington, Feb uary 9: Researchers have identified a protein that is highly expressed in triple negative breast cancer cells after chemotherapy.

Due to chemotherapy resistance and a high rate of relapse, triple negative cancers are among the most difficult breast cancers to treat.

Researchers led by Carlos Arteaga at Vanderbilt University made a mouse model of breast cancer, in which the protein both diverted cells down a path to becoming cancerous and allowed for cancer to come back after treatment.

Importantly, loss of the protein prevented tumor recurrence in mice.

These studies identify a mechanism by which cancer cells elude standard chemotherapy and provide a rationale for testing the therapeutic potential of agents that block the protein.

The study has been published in the Journal of Clinical Investigation. (ANI)