Washington, Apr 10: Natural substances extracted from unroasted coffee beans can help control the elevated blood sugar levels and body weight that underpin type 2 diabetes, new evidence has suggested.
The evidence points to chlorogenic acids- widely available as a dietary supplement – as the active ingredients in coffee that both prevent diabetes and improve glucose control in normal, pre-diabetic and diabetic people.
Joe Vinson, Ph.D., who led the research, pointed out that type 2 diabetes, the most common form of diabetes, is an increasing global health problem.
“A simple natural pill or capsule that would both help control blood sugar and foster weight loss at the same time would be a major advance in the treatment of type 2 diabetes,” Vinson said.
“Our own research and studies published by other scientists suggest that such a treatment may, indeed, exist. There is significant epidemiological and other evidence that coffee consumption reduces the risk of type 2 diabetes,” he noted.
Chlorogenic acids are a family of substances that occur naturally in apples, cherries, plums, dried plums and other fruits and vegetables.
Vinson, who is with the University of Scranton in Pennsylvania, pointed out that coffee ? due to its popularity as a beverage ? is a major dietary source of these substances. Large amounts of chlorogenic acids exist in green, or unroasted, coffee beans.
However, the high temperatures used to roast coffee beans to make them suitable for use in coffee breaks down much of the chlorogenic acids. Thus, the focus has been on using concentrated extracts of green coffee beans, which contain higher amounts of chlorogenic acids.
In a previous study, Vinson found that overweight or obese people who took such an extract lost about 10 percent of their body weight in 22 weeks. The new study sought to document the effects of various doses of a commercial green coffee extract on the blood sugar levels of 56 men and women with normal blood sugar levels.
They got a glucose tolerance test to see how their bodies responded to the sugar. Then over a period of time, they took 100, 200, 300 or 400 milligrams (mg) of the extract in a capsule with water. Follow-up glucose tolerance tests showed how the green coffee extract affected their responses.
“There was a significant dose-response effect of the green coffee extract and no apparent gastrointestinal side effects,” Vinson said.
“All doses of green coffee extract produced a significant reduction in blood sugar relative to the original blank glucose challenge. The maximum blood glucose occurred at 30 minutes and was 24 percent lower than the original with the 400 mg of green coffee extract and the blood glucose at 120 minutes was 31 percent lower,” he stated.
Vinson acknowledged funding from Applied Food Sciences, Inc., which markets a green coffee antioxidant product.
Their presentation was part of the 245th National Meeting and Exposition of the American Chemical Society (ACS), the world’s largest scientific society, being held here this week. (ANI)